Herpes Zoster in the Older Adult

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Herpes zoster in older adults.

Herpes zoster (HZ) strikes millions of older adults annually worldwide and disables a substantial number of them via postherpetic neuralgia (PHN). Key age-related clinical, epidemiological, and treatment features of zoster and PHN are reviewed. HZ is caused by renewed replication and spread of varicella-zoster virus (VZV) in sensory ganglia and afferent peripheral nerves in the setting of age-r...

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Herpes zoster vaccine in older adults and the risk of subsequent herpes zoster disease.

CONTEXT Approximately 1 million episodes of herpes zoster occur annually in the United States. Although prelicensure data provided evidence that herpes zoster vaccine works in a select study population under idealized circumstances, the vaccine needs to be evaluated in field conditions. OBJECTIVE To evaluate risk of herpes zoster after receipt of herpes zoster vaccine among individuals in gen...

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Herpes Zoster and Recurrent Herpes Zoster

BACKGROUND The incidence of recurrent herpes zoster (HZ) and the relationship between initial and recurrent HZ are not clear. METHODS The Miyazaki Dermatologist Society has surveyed ~5000 patients with HZ annually since 1997. A questionnaire regarding HZ and its recurrence was completed by the dermatologists. RESULTS A total of 34 877 patients with HZ were registered at 43 clinics between J...

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A varicella-zoster virus vaccine reduced the burden of illness of herpes zoster in older adults.

Outcomes: vaccine efficacy with respect to the severity of illness caused by herpes zoster, defined as the relative reduction in burden of illness score (VEBOI) based on the severity of herpes zoster pain and its duration, comparing the vaccine and placebo groups. For the vaccine to be considered a success, the VEBOI point estimate had to be >47% with the lower limit of the 95% CI .25%. The sec...

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Managing herpes zoster in older adults: Prescribing considerations.

NPs must be aware of special prescribing considerations for medication safety when managing the care of older adults with herpes zoster. Age-related physiologic changes of the body impact the pharmacokinetics and pharmacodynamics of antiviral and pain medications and can lead to potential adverse events.

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ژورنال

عنوان ژورنال: Infectious Disease Clinics of North America

سال: 2017

ISSN: 0891-5520

DOI: 10.1016/j.idc.2017.07.016